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OncoMed Pharmaceuticals: Novel Anti-Cancer Stem Cell Therapeutics Net Present Value (NPV) / MBA Resources

Introduction to Net Present Value (NPV) - What is Net Present Value (NPV) ? How it impacts financial decisions regarding project management?

NPV solution for OncoMed Pharmaceuticals: Novel Anti-Cancer Stem Cell Therapeutics case study


At Oak Spring University, we provide corporate level professional Net Present Value (NPV) case study solution. OncoMed Pharmaceuticals: Novel Anti-Cancer Stem Cell Therapeutics case study is a Harvard Business School (HBR) case study written by Larry Lasky. The OncoMed Pharmaceuticals: Novel Anti-Cancer Stem Cell Therapeutics (referred as “Oncomed Cancer” from here on) case study provides evaluation & decision scenario in field of Innovation & Entrepreneurship. It also touches upon business topics such as - Value proposition, Growth strategy.

The net present value (NPV) of an investment proposal is the present value of the proposal’s net cash flows less the proposal’s initial cash outflow. If a project’s NPV is greater than or equal to zero, the project should be accepted.

NPV = Present Value of Future Cash Flows LESS Project’s Initial Investment






Case Description of OncoMed Pharmaceuticals: Novel Anti-Cancer Stem Cell Therapeutics Case Study


University of California, Berkeley-Haas collectionThe OncoMed case study illustrates the significant challenges facing a company that pursues novel therapies in the biotechnology industry. This is as opposed to me-too or second generation drug companies, such as Proteolix, where the company is attempting to make an improved treatment directed against a target for which there is significant clinical validation (a challenging pursuit as well--see the Proteolix case study, also published at the Berkeley-Haas School of Business). OncoMed Pharmaceuticals was a clinical stage cancer stem cell (CSC) company founded in August 2004. The company's novel idea in cancer research was that tumors are composed of heterogeneous cell types, and that cancer growth and metastasis are driven by a sub-population of cells within the tumor coined "cancer stem cells." By 2012, although the company had no revenue and no product candidates in pivotal clinical trials or approved for sale, the team had successfully achieved significant scientific milestones that led it to file for an initial public offering on May 11, 2012. By that time, OncoMed had four clinical trials occurring and another starting later that year, thus achieving unlikely, partial success as a novel drug development company in the challenging field of biotechnology where failure far exceeded success.


Case Authors : Larry Lasky

Topic : Innovation & Entrepreneurship

Related Areas : Growth strategy




Calculating Net Present Value (NPV) at 6% for OncoMed Pharmaceuticals: Novel Anti-Cancer Stem Cell Therapeutics Case Study


Years              Cash Flow     Net Cash Flow     Cumulative    
Cash Flow
Discount Rate
@ 6 %
Discounted
Cash Flows
Year 0 (10020002) -10020002 - -
Year 1 3444120 -6575882 3444120 0.9434 3249170
Year 2 3960303 -2615579 7404423 0.89 3524656
Year 3 3951936 1336357 11356359 0.8396 3318122
Year 4 3223084 4559441 14579443 0.7921 2552984
TOTAL 14579443 12644931




The Net Present Value at 6% discount rate is 2624929

In isolation the NPV number doesn't mean much but put in right context then it is one of the best method to evaluate project returns. In this article we will cover -

Different methods of capital budgeting


What is NPV & Formula of NPV,
How it is calculated,
How to use NPV number for project evaluation, and
Scenario Planning given risks and management priorities.




Capital Budgeting Approaches

Methods of Capital Budgeting


There are four types of capital budgeting techniques that are widely used in the corporate world –

1. Net Present Value
2. Internal Rate of Return
3. Profitability Index
4. Payback Period

Apart from the Payback period method which is an additive method, rest of the methods are based on Discounted Cash Flow technique. Even though cash flow can be calculated based on the nature of the project, for the simplicity of the article we are assuming that all the expected cash flows are realized at the end of the year.

Discounted Cash Flow approaches provide a more objective basis for evaluating and selecting investment projects. They take into consideration both –

1. Magnitude of both incoming and outgoing cash flows – Projects can be capital intensive, time intensive, or both. Oncomed Cancer shareholders have preference for diversified projects investment rather than prospective high income from a single capital intensive project.
2. Timing of the expected cash flows – stockholders of Oncomed Cancer have higher preference for cash returns over 4-5 years rather than 10-15 years given the nature of the volatility in the industry.






Formula and Steps to Calculate Net Present Value (NPV) of OncoMed Pharmaceuticals: Novel Anti-Cancer Stem Cell Therapeutics

NPV = Net Cash In Flowt1 / (1+r)t1 + Net Cash In Flowt2 / (1+r)t2 + … Net Cash In Flowtn / (1+r)tn
Less Net Cash Out Flowt0 / (1+r)t0

Where t = time period, in this case year 1, year 2 and so on.
r = discount rate or return that could be earned using other safe proposition such as fixed deposit or treasury bond rate. Net Cash In Flow – What the firm will get each year.
Net Cash Out Flow – What the firm needs to invest initially in the project.

Step 1 – Understand the nature of the project and calculate cash flow for each year.
Step 2 – Discount those cash flow based on the discount rate.
Step 3 – Add all the discounted cash flow.
Step 4 – Selection of the project

Why Innovation & Entrepreneurship Managers need to know Financial Tools such as Net Present Value (NPV)?

In our daily workplace we often come across people and colleagues who are just focused on their core competency and targets they have to deliver. For example marketing managers at Oncomed Cancer often design programs whose objective is to drive brand awareness and customer reach. But how that 30 point increase in brand awareness or 10 point increase in customer touch points will result into shareholders’ value is not specified.

To overcome such scenarios managers at Oncomed Cancer needs to not only know the financial aspect of project management but also needs to have tools to integrate them into part of the project development and monitoring plan.

Calculating Net Present Value (NPV) at 15%

After working through various assumptions we reached a conclusion that risk is far higher than 6%. In a reasonably stable industry with weak competition - 15% discount rate can be a good benchmark.



Years              Cash Flow     Net Cash Flow     Cumulative    
Cash Flow
Discount Rate
@ 15 %
Discounted
Cash Flows
Year 0 (10020002) -10020002 - -
Year 1 3444120 -6575882 3444120 0.8696 2994887
Year 2 3960303 -2615579 7404423 0.7561 2994558
Year 3 3951936 1336357 11356359 0.6575 2598462
Year 4 3223084 4559441 14579443 0.5718 1842809
TOTAL 10430716


The Net NPV after 4 years is 410714

(10430716 - 10020002 )








Calculating Net Present Value (NPV) at 20%


If the risk component is high in the industry then we should go for a higher hurdle rate / discount rate of 20%.

Years              Cash Flow     Net Cash Flow     Cumulative    
Cash Flow
Discount Rate
@ 20 %
Discounted
Cash Flows
Year 0 (10020002) -10020002 - -
Year 1 3444120 -6575882 3444120 0.8333 2870100
Year 2 3960303 -2615579 7404423 0.6944 2750210
Year 3 3951936 1336357 11356359 0.5787 2287000
Year 4 3223084 4559441 14579443 0.4823 1554342
TOTAL 9461653


The Net NPV after 4 years is -558349

At 20% discount rate the NPV is negative (9461653 - 10020002 ) so ideally we can't select the project if macro and micro factors don't allow financial managers of Oncomed Cancer to discount cash flow at lower discount rates such as 15%.





Acceptance Criteria of a Project based on NPV

Simplest Approach – If the investment project of Oncomed Cancer has a NPV value higher than Zero then finance managers at Oncomed Cancer can ACCEPT the project, otherwise they can reject the project. This means that project will deliver higher returns over the period of time than any alternate investment strategy.

In theory if the required rate of return or discount rate is chosen correctly by finance managers at Oncomed Cancer, then the stock price of the Oncomed Cancer should change by same amount of the NPV. In real world we know that share price also reflects various other factors that can be related to both macro and micro environment.

In the same vein – accepting the project with zero NPV should result in stagnant share price. Finance managers use discount rates as a measure of risk components in the project execution process.

Sensitivity Analysis

Project selection is often a far more complex decision than just choosing it based on the NPV number. Finance managers at Oncomed Cancer should conduct a sensitivity analysis to better understand not only the inherent risk of the projects but also how those risks can be either factored in or mitigated during the project execution. Sensitivity analysis helps in –

What are the key aspects of the projects that need to be monitored, refined, and retuned for continuous delivery of projected cash flows.

Understanding of risks involved in the project.

What will be a multi year spillover effect of various taxation regulations.

What can impact the cash flow of the project.

What are the uncertainties surrounding the project Initial Cash Outlay (ICO’s). ICO’s often have several different components such as land, machinery, building, and other equipment.

Some of the assumptions while using the Discounted Cash Flow Methods –

Projects are assumed to be Mutually Exclusive – This is seldom the came in modern day giant organizations where projects are often inter-related and rejecting a project solely based on NPV can result in sunk cost from a related project.

Independent projects have independent cash flows – As explained in the marketing project – though the project may look independent but in reality it is not as the brand awareness project can be closely associated with the spending on sales promotions and product specific advertising.






Negotiation Strategy of OncoMed Pharmaceuticals: Novel Anti-Cancer Stem Cell Therapeutics

References & Further Readings

Larry Lasky (2018), "OncoMed Pharmaceuticals: Novel Anti-Cancer Stem Cell Therapeutics Harvard Business Review Case Study. Published by HBR Publications.


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